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Name: methyl-beta-cyclodextrin
Other name : methyl-β-cyclodextrin
CAS: 128446-36-6
Abbreviation: MEBCD
Molecular formula : C42H70-nO35 · (CH3)n
Molecular weight: 1135 + n•(14.0)
Solubility(in 100cm3 solvent, at 25℃) : water: >50g
Methanol: >50g
Chloroform: ~ 2 g
Standard : enterprise standard
Package: 500g/bag , 1kg/bag, 10kg/drum or customized
Use : medical \ chemical \ other industries
Description
Appearance |
white powder, insipid, innocent |
Qualify |
Assay |
≥98％ |
99.6% |
Degree of Substitution |
11.2-13.3 |
13.0 |
Molar of substitution |
1.6-1.9 |
1.8 |
Loss on Drying |
≤5.0％ |
3.9% |
Optical density of a 10%solution (220-350nm) |
≤1.0 |
Qualify |
Optical density of a 10%solution (350-600nm) |
≤0.1 |
Qualify |
Chloride |
≤0.2％ |
≤0.05％ |
Unsubstituted cyclodextrin |
≤0.3％ |
Absent |
Residue on Ignition |
≤0.5％ |
0.39% |
Heavy Metal (as pd) |
≤0.0001% |
＜0.0001% |
Arsenic salt (AS) |
≤0.0005% |
＜0.0005% |
Specific rotation |
154º-165º |
156.2º |
Solubility in water(25℃) |
>750g/L |
Qualify |
TAMC(cfu/g) |
≤1000 |
10 |
TYMC(cfu/g) |
≤100 |
10 |
Salmonella/E. Coli (cfu/g) |
Absent |
Absent |
Storage: at room temperature, in tightly closed container.
Characteristics and applications：
Methylated-β-cyclodextrin (Me-β-CD) is one of cyclodextrin derivatives that were widely used in modern researches and applications.
Me-β-CD can be soluble both in water and in organic solvents. In pharmaceuticals industry, it can increase solubility and bioavailability of drugs, so that the efficacy of drugs can last longer with less ingestion. It can adjust and control the drug release rate, reduce drug side-effects, and enhance the stability of drugs particularly for oil-soluble molecules.
In commodity chemicals and cosmetics, Me-β-CD can reduce microbial contamination and skin irritations, keep skin moist, mask bad odors, promote transdermal absorption of activeingredients.
Me-β-CD has a larger surface tension in common cyclodextrin derivatives.
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